阿奇霉素和氯霉素治疗恙虫病的效果比较.docVIP

阿奇霉素和氯霉素治疗恙虫病的效果比较 　　[摘要] 目的 探讨阿奇霉素和氯霉素治疗恙虫病的临床效果。 方法 选择2009年6月～2012年10月于本院进行诊治的46例恙虫病患者，随机分为观察组和对照组，每组各23例。观察组给予阿奇霉素静脉滴注治疗，对照组给予氯霉素静脉滴注治疗，比较两组的治疗效果及不良反应发生率情况。 结果 两组的体温恢复正常时间、淋巴结肿痛治愈时间和焦痴脱落时间比较，差异无统计学意义（P0.05）；观察组不良反应发生率为8.7%，对照组不良反应发生率为34.8%，两组比较差异有统计学意义（χ2=4.600，P=0.032）。 结论 阿奇霉素与氯霉素作为临床常用的抗生素类药物，对恙虫病的治疗效果基本相当，但阿奇霉素对患者集体的毒副作用更小，可替代氯霉素在临床上治疗恙虫病。 　　[关键词] 阿奇霉素；氯霉素；恙虫病 　　[中图分类号] R757.9 [文献标识码] A [文章编号] 1674-4721（2014）09（b）-0111-03 　　Effect comparison of azithromycin and chloramphenicol in the treatment of tsutsugamushi disease 　　LI Zhi-cun 　　Department of Pharmacy，the Third People′s Hospital of Dongguan City in Guangdong Province，Dongguan 523321，China 　　[Abstract] Objective To explore clinical effect of azithromycin and chloramphenicol in the treatment of tsutsugamushi disease. Methods 46 cases with tsutsugamushi disease from June 2009 to October 2012 in our hospital were selected and randomly divided into observation group and control group，23 cases in each group.The observation group was treated with azithromycin，and the control group was treated with chloramphenicol.The treatment effect and the adverse reaction of two groups were compared respectively. Results There was no statistical difference in normal temperature time，lymph node swelling cure time and eschar shedding time between two groups （P0.05）.The incidence rate of adverse reaction in the observation group was 8.7%，while the incidence rate of adverse reaction in the control group was 34.8%，with statistical difference（χ2=4.600，P=0.032）. Conclusion As clinical commonly used antibiotics，azithromycin and chloramphenicol have both good effect on tsutsugamushi disease.But azithromycin has less toxic and side effects on patients，compared with chloramphenicol，and can replace chloramphenicol in the treatment of tsutsugamushi disease. 　　[Key words] Azithromycin；Chloramphenicol；Tsutsugamushi disease 　　恙虫病又称丛林斑疹伤寒，主要由带有恙虫病东方体的恙虫幼虫叮咬而引发，临床上以叮咬部位焦痂形成、体温骤升、淋巴结发炎肿胀、皮疹以及周围血液白细胞数降低等为特征[1]。氯霉素作为抗感染药已在临床使用多年[2]，疗