第3章 缩合反应1.pptVIP

Chapter 3 Condensation reactions 三 Mannich反应实例 The Wittig Reaction Synthetic method for preparing alkenes. One of the reactants is an aldehyde or ketone. The other reactant is a phosphorus ylide. Charge distribution in a ylide The Wittig Reaction Example dimethyl sulfoxide (DMSO) or tetrahydrofuran (THF) is the customary solvent Mechanism Mechanism Retrosynthetic Analysis There will be two possible Wittig routes toan alkene. Analyze the structure retrosynthetically. Disconnect the doubly bonded carbons. One will come from the aldehyde or ketone, theother from the ylide. Retrosynthe