viewslides-pffsummit2017.pptVIP

PFF Teal = 0+160+175 MAIN COLORS PFF Green = 120+162+47 Light Green = 193+216+47 Red = 242+102+73 HIGHLIGHT COLORS Light Grey = 220+220+210 Dark Grey = 100+98+76 Black = 0+0+0 ?2015 Pulmonary Fibrosis Foundation. All rights reserved. PFF Teal = 0+160+175 MAIN COLORS PFF Green = 120+162+47 Light Green = 193+216+47 Red = 242+102+73 HIGHLIGHT COLORS Light Grey = 220+220+210 Dark Grey = 100+98+76 Black = 0+0+0 ?2015 Pulmonary Fibrosis Foundation. All rights reserved. Plenary session and panel discussion: the future of clinical trials in pulmonary fibrosis LEADERS: DAVID J. LEDERER, MD, MS; KEVIN K. BROWN, MD PANEL: WILLIAMSON BRADFORD, MD, PhD; A. BRUCE MONTGOMERY, MD; FERNANDO J. MARTINEZ, MD, MS; JANET WOODCOCK, MD; R. BRUCE SNYDER; DOUG JONES NOVEMBER 13, 2015 Survival of IPF patients is short Turner-Warwick et al, Thorax, 1980 Median survival - 5 years …even shorter than we thought King et al, Am J Respir Crit Care Med, 2000 Median survival – 2.8 years Meier-Sydow et al, Prax Pneumol, 1979 Early treatment in IPF Cyclophosphamide treatment in IPF 43 patients with Cryptogenic Fibrosing Alveolitis Prednisone alone 60mg/day x 4 wks. tapered 20mg/qod Prednisone + Cyclophosphamide 100-120mg/po/qday Johnson et al, Thorax, 1989 1 2 3 4 6 Years 0 50 100 % Still Alive Prednisolone Prednisolone + cyclophosphamide p 0.1 Azathioprine treatment in IPF Raghu et al, Am Rev Respir Dis, 1991 Survival Probability Years 1.0 0.8 0.6 0.4 0.2 0 0 1 2 3 4 5 6 7 8 9 Azathioprine + Prednisone Prednisone The AVONEX? IPF Study Efficacy of Interferon β-1a in the Treatment of Idiopathic Pulmonary Fibrosis (IPF) The AVONEX? IPF Study Multicenter, randomized, double-blind, placebo-controlled dose-ranging study. Conducted at 34 centers in US and Canada. 167 subjects were enrolled from April 1998 to October 1999. Subjects randomized to receive Interferon β-1a 15, 30, or 60 mcg or placebo IM twice weekly for a minimum of 12 months and up to 2 ? years. The AVONE