21thWCC,Shenzhen,China,Aug19,2010Guo-LiangJiang,.pptVIP

Gefitinib enhanced radiosensitivity of tumor cells Survival curve of Oral SCC (in vitro) Gefitinib enhanced radiosensitivity of tumor cells GEO (rectal carcinoma) in vivo (tumor re-growth delay) 10Gy/fx×4fx + Iressa 2.5mg ip d1-5×4 wks The percentage of S phase decreased after IressaIressa+RT (GEO in vivo) Gefitinib speeds up apoptosis of tumor cells after RT GEO in vivo Gefitinib inhibits RT induced damage repairOral SCC (Western blot) Iressa+RT in Oral SCC (Western blot) Possible mechanisms for radiosensitization of Gefitinib Decrease percentage of S phase and increase G