GeneRelatedMetabolismofDrugs.pptVIP

Gene Related Metabolism of Drugs Anastasios Maratonitis (2009) There are more than 30 families of drug-metabolizing enzymes in humans, and essentially all have genetic variants, many of which translate into functional changes in the proteins encoded. The cytochrome P-450 enzymes, a superfamily of microsomal drug-metabolizing enzymes, are the most important of the enzymes that catalyze phase I drug metabolism. One member of this family, cytochrome P-450 2D6 (CYP2D6) will be used as example of gene variation in drug metabolism. More than 75 CYP2D6 alleles have been described, subjects with ultr