Data Analysis manuscript .doc

HEART: An Automated Beat-to-Beat Cardiovascular Analysis Package Using Matlab? Mark J. Schroeder1,2, Ph.D., Bill Perreault2, M.S., Daniel L. Ewert1,2, Ph.D., and Steven C. Koenig1, Ph.D. 1Jewish Hospital Heart and Lung Institute, Department of Surgery, University of Louisville, Louisville, KY 40202 2Cardiovascular Research Laboratory, Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND 58105 *Funding provided by a grant from the Jewish Hospital Heart and Lung Institute Running Title: Hemodynamic Beat-to-Beat Analysis Word Count: 5899 Address Correspondence To: Mark J. Schroeder, Ph.D. Steven C. Koenig, Ph.D. Electrical and Computer Engineering Dept. Cardiovascular Research Center North Dakota State University 500 South Floyd Street Fargo, ND 58105 Department of Surgery PH: (701)-231-8049 University of Louisville FAX: (701)-231-8677 Louisville, KY 40202 Email: emailmjs@ PH: (502)-852-4416 FAX: (502)-852-1795 E-mail: sckoen01@Abstract A computer program is described for beat-to-beat analysis of cardiovascular parameters from high-fidelity pressure and flow waveforms. The Hemodynamic Estimation and Analysis Research Tool (HEART) is a post-processing analysis software package developed in Matlab? that enables scientists and clinicians to document, load, view, calibrate, and analyze experimental data that has been digitally saved in ascii or binary format. Analysis routines include traditional hemodynamic parameter estimates as well as more sophisticated analyses to estimate lumped arterial model parameters and vascular impedance frequency spectra. Cardiovascular parameter values of all analyzed beats can be viewed and statistically analyzed. The most attractive feature of the HEART program is the ability to analyze data with visual quality assurance throughout the process establishing a framework toward which Good Laboratory Practice (GLP) compliance can be obtained. A