Mass spectral.ppt

Mass spectral profiling: An effective tool for quality control of herbal medicines Keywords: Mass spectral profiling Gas chromatography–mass spectroscopy Houttuynia cordata Thunb Herbal medicine Chemometrics Abstract 1.mass spectral profiling is a new tool for data processing; 2.main idea : employment of target m/z points of GC–MS data; 3.advantages: a.the qualitative and quantitative information will be mined out effectively; b.assess the importance of target compositions; c.less data points to get the rich information; d.powerful for quality control. 4. material: Houttuynia cordata Thunb; its finished injection products. 5.The good performance of mass spectral profiling shows that it can be a promising tool in the future studies of complex mixture systems. Introduction 1.Herbal medicines (HMs) and other folk medicines are well organized as very complicated multi-component systems with hundreds or even thousands of chemical components. consequences: a.difficult (quality control,discovery of active constituents); b.main drawbacks ( internationalization and globalization). conclusion: make HMs meet the globally acceptable criteria. 2.The quantity and quality of the safety and efficacy data on traditional medicine are far from sufficient to meet the criteria needed to support its use worldwide. reasons:a.health care policies; b.lack of adequate or accepted research methodology. 3.Chromatographic fingerprint has been developed to control and evaluate the quality of HMs. 4. quality controls important steps : (1)extraction and discovery; (2)processing 5.PCA , EFA, HELP , SFA, AMWFA a.find information(but most of them only attempted to find the information of pure components of HMs, not regard them as a whole); b.difficult to understand “synergic effects”. 6.In thiswork, mass spectral profilingis used to extr