Parham Metabolic diseases handout.docVIP

METABOLIC DISEASES David M. Parham, M.D. Director, Pediatric Pathology Professor of Pathology; University of Oklahoma Health Science Center Why should anatomic pathologists study metabolic disease? Pediatric metabolic disease can have a wide range of clinical presentations, often in early life Presentations include a mixture of:?? neuromuscular disorders failure to thrive acute exacerbations May be precipitated by infections May cause unexpected demise or mysterious illness Dietary management may prevent further disease Diagnosis of metabolic disease Definitive diagnosis is usually not