locanesth !!!.pptVIP

Local anesthetics Local anesthetics History of Local Anesthetics Structure of LAs LAs: mechanism of action LAs: mechanism of action (cont.) Kinetics of analgesia during nerve block Differential sensitivity of nerve fibers to LAs Epinephrine/ LA mix Hypotensive effects of LAs Effects of LAs on heart Other effects of LAs Various types of LA * Mechanism of action: block of fast Na channels in axons Major desired effect: blockade of action potentials in nociceptive sensory afferents to relieve pain. Major unwanted side-effects: cardiac arrhythmias, vasodilation (hypotension) convulsions d