ICU或脓毒血症液体复苏摘要.ppt

——白蛋白的使用 HES 130/0.4 vs saline (CHEST study): safety and efficacy in the ICU? AKI, acute kidney injury; CHEST, Crystalloid versus Hydroxyethyl Starch Trial; HES, hydroxyethyl starch; ICU, intensive care unit; RIFLE, risk, injury, failure, loss and end-stage kidney injury; RRT, renal replacement therapy Myburgh et al. N Engl J Med 2012; 367: 1901–1911 Aim Evaluate safety of HES 130/0.42* vs saline in ICU patients Study design Multicentre, parallel group, blinded, randomised Comparison 6% HES 130/0.4 (N=3315) 0.9% saline (N=3336) Maximum daily dose: 50 mL/kg body-weight/day However, the mea