Seminar-纖維和血糖控制.ppt

* IGF-1在血中多和IGFBP-3結合 * EN可幫助血漿tocopherol 的維持，其他數據都沒有顯著差異 * Plasma glutamine concentrations were higher in the IV AG group versus the control and ENAG groups after 8 days of treatment. * p=0.039 versus baseline values. * * This study demonstrates that IV alanyl-glutamine supplementation for 7 days increases total plasma glutathione levels in critically ill trauma patients receiving standard enteral nutrition. * 本篇實驗設計覺得之前相關設計的介入時間太短，之前實驗結果至少要五天以上才有功效 * * Intravenous Glutamine Supplementation in Critically Ill Patients Receiving Enteral Feeding Reporter: 黃孜立 Instructor: 賴聖如 營養師 * Abstract Glutamine and Dipeptiven Metabolism under stress Paper Metabolic Effects Of Enteral Versus Parenteral Alanyl-glutamine Dipeptide Administration In Critically Ill Patients Receiving Enteral Feeding: A Pilot Study The Effect Of Intravenous Alanyl-glutamine Supplementation On Plasma Glutathione Levels In Intensive Care Unit Trauma Patients Receiving Enteral Nutrition: The Results Of A Randomized Controlled Trial Effect Of Intravenous Glutamine Supplementation IN Trauma Patients Receiving Enteral Nutrition Study Protocol (GLINT Study): A Prospective, Blinded, Randomised, Placebo Controlled Clinical Trial Conclusion * What is Glutamine (GLN) ? * Endogenous Glutamine Plasma Glutamine concentrations↑, improve: Antioxidant capacity Nitrogen balance ↑ Immune function ↑ Intestinal permeability ↑ The incidence of hospital-acquired infection ↓ * Hypermetabolic response * Metabolism under stress * Stress hypermetabolism REE ↑↑ Respiratory quotient 0.8-0.9 Proteolysis ↑↑ Hepatic protein synthesis ↑↑ Ureagenesis ↑↑ Gluconeogenesis ↑↑ Urinary nitrogen loss ↑↑ * Glutamine Therapy Dipeptiven雙胜胺 * Concentrated GLN solution containing the dipeptide alanyl-glutamine (Ala-Gln) 100 ml contains: 20 g N(2)-L-alanyl-L-glutamine =13.46 g L-glutamine, 8.20 g L-alanine(= 3.87 g N) -Water for injection -Theoretical osmolarity: 921 mosmol/ l Indication In patients in catabolic and/ or hypermetabolic st