single cell line analysis reveals FMDV persistent and EBP expression.docxVIP

Title: Single cell analysis reveals foot-and-mouth disease virus persistence to EBP gene expression in host cellsAbstractFoot-and-mouth disease virus (FMDV), a member of the Picornaviridae family, usually infects host cells in an acute or persistent manner. In this study, we examined the relevance of FMDV persistence establishment to the expression of EBP gene in BHK-21 host using 231 persistently infected single cells after passages 28、38 and 68 (PI28, PI38 and PI68), respectively. Our results indicate there are dynamic changes in the expression of viral 3D and host cell EBP genes at differen