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Unit 1 Causes of depression Hello, everyone. Today I invite you to join me in an exploration of the causes of depression. There are many factors involved, but I believe some deserve special attention. Heredity certainly plays a role. The tendency to develop depression may be inherited; there is evidence that this disorder may run in families. Physiology is another factor related to depression. There may be changes or imbalances in chemicals which transmit information in the brain, called neurotransmitters. Many modern antidepressant drugs attempt to increase levels of certain neurotransmitters