E-2-2-6-氯嘧啶-4-基氧基苯基-3-甲氧基丙烯酸甲酯合成工艺试验小结.docVIP

(E)-2-{2-[6-(2-氰基苯氧基)嘧啶-4-基氧]苯基}-3-甲氧基丙烯酸甲酯 合成工艺试验小结 王一军 （亚邦化工连云港有限公司，连云港，222523） 摘 要：邻氯苯乙酸在0.85Mpa、8-羟基喹啉铜催化下水解自制邻羟基苯乙酸在乙酸成环甲氧甲烯化rocess Experiment on Synthesis of Methyl(E)-2-{2-[6-(2-cyanophenoxy) pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate WANG Yi-jun (Yabang Chemical Group Co., Ltd(Liangyungang), Liangyungang, 222523, China) Abstract: In 0.65Mpa,2-chlorophenylacetic acid and NaOH prepared 2-hydroxyphenylacetic acid by catalytic hydrolysis of copper 8-quinolinolate.Then benzofuran-2(3H)-one(Ⅰ) was cyclized by dehydration and esterification, (Ⅰ) reacted with CH(OCH3)3 and (CH3CO)2O to