纳米制剂学习课件.pptVIP

Stability of nano-preparation 纳米药物(nano-drug) 定义 将药物的微粒或者将药物吸附包裹在特定载体中，制成纳米尺寸范围内的微粒，然后以其为基础制成不同种类的剂型。 Comparison Ethnodrug 药物微粒大、表面反应活性低、活性中心少、催化效率低、吸附能力弱，并且对人体的毒性较大，疗效却不佳，且存在严重的量效效应，即疗效—剂量依赖关系 Adhesiveness Change mechanism of membrane transport Controlled release：the use of carrier material, can slow dissolution The stability of nano-preparation Nanomedicine crystal stability is affected by many factors : formulation types(dry powder, nano-suspension ) dispersion medium (aqueous and non-aqueous)