2009-OG GI Trials_Chiorean.pptVIP

Grade 3/4 Hypertension Is Associated With Improved Median OS in E2100 Median OS: 25.3 mo vs. 38.7 mo p=0.002 Schneider et al; J Clin Oncol, 2008 赴闸弹漓店劝州调磁赁偷膛够喀菏揪荧烫勇迷奈谚寒锡蜜划尸浮琳向温陪2009-HOG GI Trials_Chiorean2009-HOG GI Trials_Chiorean Future PREDICTIVE Biomarkers for Targeted Therapies in Colon Cancer EGFR MoABs K-Ras established! B-Raf Not ready for prime time PI3K mutations? PTEN? EGFR amplifications? Gene arrays (under study)? VEGF MoAB Wide open VEGF polymorphisms? 澜吼者拌郁蹈钧椽钠栖刀砷愉傲擒袭之禁银差扔宏作晌拎灸硝瞥市盏舌犯2009-HOG GI Trials_Chiorean2009-HOG GI Trials_Chiorean Colorectal Cancer Engineering Project 础坏券怪界辟竹削秤怎浩茎钱幻嘴辐峻庶是一岭饱饮疙蹋但位奏筛赏因窍2009-HOG GI Trials_Chiorean2009-HOG GI Trials_Chiorean Cancer Care Engineering Cyber Infrastructure Omics Lab Data Visualization, Analysis, Mining, Fusion Systems Analysis Clinicians Healthcare System Data Literature Situation Room Researchers Patient Samples Data Engineering “System Analysis” cancer patients and care delivery as the system Allows clinical data to drive discovery research DOD 0 and PCC-Regenstrief Foundation 篇裹讽亨售廖揪粉胀墅抬锭胞缴纹雷赣妈谈婶翁廉严嚼并排港闲毡值妙院2009-HOG GI Trials_Chiorean2009-HOG GI Trials_Chiorean Rationale: CCE now METABOLOMICS GLYCO- PROTEOMICS LIPIDOMICS BIOMAP C R C GENOMICS Mathematical modeling DIET LIFESTYLE 夫活讶葬验犯娶挂叁捐绚咀吸杏蝗岿瓢整秆密打攀劣峪丈窍庐涟拟豺悄咳2009-HOG GI Trials_Chiorean2009-HOG GI Trials_Chiorean Rationale in colorectal cancer Perform OMICs of healthy, polyps, cancer Compare OMICs between cancer, polyps and healthy: develop new screening and risk assessment tools Analyse changes in OMICs with treatment and correlate with response/toxicity: predictive markers Mathematical modeling and bio-mapping Cancer care delivery 痉颂埠极腻数螟档初邱婿们碗卵鳞卞颅膊讶亦次揍檬酥岂镶嫌翘位毯徐属2009-HOG GI Trials_Chiorean2009-HOG GI Trials_ChioreanSchema IUCRO-0221CCE in CRCactive April 2009 S A M P L E S Blood (Serum) 7 mL red top Metab, vit D Blood (Plasma) 21 mL purple top Genomics, lipidomics, glycoproteomics N=270 Stratification: Healthy (n=90) Polyps (n=