Anti-HIV-1activityoffiveanthraquinonederivatives.docVIP

Anti-HIV-1 activity of five anthraquinone derivatives* OUYANG Dong-yun, LIU Chun-yong, ZENG Yao-ying△, HE Xian-hui, ZENG Xiang-feng (Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China) [ABSTRACT] AIM: To investigate the anti-HIV-1 activity of five anthraquinone derivatives (emodin, rhein, chrysophanol, physcion and aloe-emodin) in vitro. METHODS: Viral replication was estimated by observation of cytopathogenesis and measurement of HIV-1 p24 antigen production in HIV-1IIIB acutely infected C8166 cells. The anti-