已修改-核心文章-(急性冠状动脉综合征患者TIMI危险积分与血浆N末端前脑利钠肽(NTpro-BNP)肌..docVIP

急性冠状动脉综合征患者TIMI危险积分与血浆N末端前脑利钠肽（NTpro-BNP）、肌钙蛋白I的相关性研究 【摘要】目的 探讨急性冠状动脉综合征患者TIMI危险积分与血浆N末端前脑利钠肽（NTpro-BNP）水平及血清肌钙蛋白I(TNI)的相关性。方法 收集2013年5月-2014年9月在我院接受治疗的98例急性冠状动脉综合征患者，按照患者的临床指标对患者进行TIMI危险评分，根据评分将患者分为低危、中危、高危，采用AQT快速免疫分析法检测患者血浆（NTpro-BNP）水平及TNI水平，研究TIMI危险积分、NTpro-BNP水平及TNI的相关性。结果 TIMI评分在单支、双支、三支病变具有差异性，说明TIMI评分能够准确的评价患者的病情，P＜0.01，差异具有统计学意义。临床上对于不同疾病的分类上具有一致性，P＜0.01，差异具有统计学意义。TIMI危险评分能够有效的预测患者的心血管不良事件发生情况，其中三组患者6个月都较3个月和治疗期的不良事件发生率高，高危组各个时期的不良事件发生率较低危和中危组高，P＜0.01，差异具有统计学意义。低危组、中危组、高危组患者随着TIMI危险评分的升高，NTpro-BNP和BNP水平均升高，NTpro-BNP升高更加显著，都可以用于识别高危患者，Spearman 等级相关分析可知，NTpro-BNP与 TIMI正相关 TNI 正相关；TIMI 与 TNI 相关性无统计学意义，无相关性急性冠脉综合征患者TIMI危险积分与NTBNP相关性良好，与NTBNP一样用于识别高危患者，而且与TNI无相关性In patients with acute coronary syndrome TIMI risk score and plasma N terminal pro brain natriuretic peptide (NTpro-BNP), correlation of troponin I [Abstract] Objective To discussion the patients with acute coronary syndrome TIMI risk score and plasma N terminal pro brain natriuretic peptide (NTpro-BNP) level and serum troponin I (TNI) correlation. Methods 98 cases of acute coronary artery from 2013 May -2014 year in September treated in our hospital in patients with syndrome TIMI risk score, integral to its clinical predictor variables, and dangerous levels of hierarchical, AQT in plasma of patients with rapid immunoassay method detection (NTpro-BNP) and TNI level, analyze the relationship between it and TIMI risk score different levels of.Results The TIMI score has the difference in single,double branch,the three branch lesions,indicating that TIMI score can accurately evaluate the patients condition, P 0.01, with significant difference.Clinical on have consistency for classification of different diseases, P 0.01, with significant difference. The TIMI risk score to predict effectively the occurrence in patients with cardiovascular adverse events, including adverse events of three groups of patients 6 months compared with 3 months of treatment period and the high incidence of adverse events in the hi