2型糖尿病的现代认知与SGLT2抑制剂的作用机制.pptVIP

* This graph then summarizes the anticipated effect of 30 to 50% blockade of the proximal tubular glucose reabsorption capacity using chemicals that promote competitive inhibition of the SGLT-2 specific in the kidney. ? Again, the y axis represents the rate of filtration, reabsorption and excretion of glucose by the kidney versus plasma glucose concentration in the x axis. The blockade shifts the curve to your left and the new threshold is reached when plasma glucose is at or around 100-140 glucose. Thus, glucose is lost in the urine at a lower concentration level [Tm]. Note that the startin