米氮平合用归脾丸治疗精神分裂症后抑郁疗效观察.docVIP

米氮平合用归脾丸治疗精神分裂症后抑郁疗效观察 林跃泉 陈祖金 范红 聂红 袁洪彬 【摘要】 目的 观察米氮平合用归脾丸治疗精神分裂症后抑郁疗效及不良反应。方法 将60例精神分裂症后抑郁患者随机分为合用组与米氮平组,疗程均为8周，于治疗前与治疗后2、4、8周后采用汉密尔顿抑郁量表(HAMD) 评定疗效，不良反应采用量表（TESS)评定。结果 合用组有效率93%,米氮平组有效率73% ,合用组有效率与米氮平组相比有统计学差异（χ2=4.32,P＜0.05）；两组在治疗2周后起与治疗前相比HAMD评分均有统计学差异（P＜0.05）；治疗2、4、8周后合用组HAMD评分与米氮平组相比均有统计学差异（P＜0.05）。结论 米氮平合用归脾丸治疗精神分裂症后抑郁的疗效优于单用米氮平，是一种较为理想的治疗方法。 【关键词】精神分裂症后抑郁；中西医结合；治疗 Study integrative medicine on treatment of past-schizophrenia depression LIN yao-quan，CHEN zu-jin，FAN hong，NIE hong，YUAN hong-bin．Minkang hospital of Suining in Sichuan province，Suining 629000，China． 【Abstract】Objective:To explore integrative medicine on treatment of past-schizophrenia depression. Methods: 60 cases of patients with past-schizophrenia depression were randomly assigned to Integrative Medicine and Mirtazapine respectively for 8 weeks. Hamilton Depression Rating Scale for Depression（HAMD）were used to evaluate and compare before and after treatment for 2、4、8 weeks.Resluts: The clinical excellent efficacy reached 93% by Integrative Medicine and 73% by Mirtazapine after being treated. There were significantly in the two groups (P0.05). There were no significant difference between Integrative Medicine and Mirtazapine in the scores of HAMD before being treated (P0.05). After being treated for 2、4、8 weeks, scores of HAMD were significantly higher in the Mirtazapine than those in the Integrative Medicine (P0.01). Scores of HAMD were significantly lower after being treated for 2、4、8 weeks than before being treated in the tow groups (P0.05), there were significantly higher (P0.01).Conclusions: The Integrative Medicine have an advantage over the Mirtazapine in the treatment of past-schizophrenia depression.It is a optimal means that the integrative medicine treats the past-schizophrenia depression. 【Key words】Schizophrenia；Depression；Integrative medicine；Guipi Wan；Mirtazapine 精神分裂症是一种常见的病因未明的精神疾病，抑郁症状是其常见的症状之一，精神分裂症后抑郁的发生率为20%～70%，而正常人群的发生率仅为10%[1]。抑郁症状可出现在精神分裂症病程中的各个阶段。它的存在不仅显著加剧了患者因精神