《放疗联合化疗治疗脑移.pptVIP

放疗联合TKI治疗肺癌脑转移 山东肿瘤医院 李宝生 Gefitinib enhanced radiosensitivity of tumor cells -percentage of S phase decreased after Iressa Iressa+RT Gefitinib speeds up apoptosis of tumor cells after RT Gefitinib inhibits RT induced damage repair (Western blot) --Iressa+RT (Western blot) WBI+Gefitinib治疗 NSLC脑转移 Four (19%) and 13 patients (62%) :CR and PR MPFS and OS: 10.0 months (95% CI: 7.5–12.5 months) and 13.0 months (95% CI: 8.2–17.8months) The most frequent toxicities included rash (86%) and diarrhea (43%), with only 3 patients developing a grade III diarrhea Gender and