绿原酸的体内过程.docVIP

绿原酸的体内过程研究 魏玮 048011147 Abstract：To summarize chlorogenic acid in absorption site and mechanism， metabolic site and pathways，and effect on pharmcokinetic parameters of chlorogenic acid with crude drugs compatibility．Recent relevant information and references were summarized，and further analyzed and reviewed．The current study showed that chlorogenic acid could be absorbed in the stomach，small intestine and large intestine，which was absorbed into the bloodstream in the original form by the stomach and small intestine． In addition，the absorption of chlorogenic acid was also affected by fasting or satiety． The main metabolic part of chlorogenic acid was in the intestine，as well as some in the liver． Chinese compatibility can promote the absorption and distribution of chlorogenic acid in the body in order to quickly reach peak concentration． We should carry out further studies on the main absorption site，mechanism of absorption in the stomach，the role of the metabolites of chlorogenic acid on its activity，and provide useful references to understand the process of chlorogenic acid in vivo，explore the association between absorption and metabolism with activity，and study pharmacokinetic． Key words：chlorogenic acid; absorption; metabolism; pharmacokinetic 摘要：绿原酸的药理活性相当广泛，其抗氧化作用非常显著，近年来逐渐成为国内外研究的热点。本文综述了绿原酸在体内吸收、分布、代谢和排泄的具体过程。 关键词:绿原酸、体内过程、 前言：绿原酸 (Chlorogenic acid) 是由咖啡酸 (Caffeicacid) 与奎尼酸(Quinic acid) 组成的缩酚酸 ,异名咖啡单宁酸 ,是植物体在有氧呼吸过程中经莽草酸途径产生的一种苯丙素类化合物。绿原酸是一种重要的生物活性物质 ,具有抗菌、抗病毒、增高白血球、保肝利胆、抗肿瘤、降血压、降血脂、清除自由基和兴奋中枢神经系统等作用[1]。它是许多中药材的有效成分之一 ,又是某些成药的质量指标。绿原酸应用非常广泛 ,主要为医药、日用化工和食品等行业。随着临床用药的多样化，由含绿原酸药物在药动学环节上的相互作用所引起的不良反应也是一个亟待解决的问题，现对其体内过程(包括吸收、分布、代谢和排泄)以及在这些环节上可能存在的药物相互作用作一综述。 1绿原酸的体内过程 1．1药动学过程 何心等[2]研究表明，绿原酸经大鼠颈静脉给药(1.2 mg／kg)后在体内呈二室开放模型分布，药动学参数Vc=O．08L，Ke=3．48h-1，K12=2．44h-1，K2l=1．05h-1，T1／2=O．20h，α=6．51h-1，β=0．62h-1，AUC=2．32g．h．ml-1。这些药动学参数并不能代表中药复方中绿原酸的药动学行为，如双黄连粉针60mg/kg经大鼠静脉给药后，绿原酸在体内仍呈二室模型，其药动学参数为Ve=O．09L，Ke=0．68h-1，K12=2．66h-1，K21=1．67h-1，T1／2