夹层合并肺损伤夹层合并肺损伤.doc

急性主动脉夹层合并急性肺损伤患者 细胞因子表达的分析 李明，法宪恩*，杨景学，赵根尚，王宏山，王寒，黄真锋 郑州大学第二附属医院心血管外科 郑州 450014 【摘要】目的 观察急性主动脉夹层合并急性肺损伤患者血清中细胞因子浓度的变化。方法 我院2010年7月-2013年12月收治急性主动脉夹层患者37例，于入院时采集患者血液，进行血气分析，同时测定血清样本中IL-6、IL-8、TNF-a的浓度。随机选择体检健康者20例抽取血液进行对照。结果 急性主动脉夹层患者与健康对照组相比，血清IL-6、IL-8和TNF-a浓度均明显升高，差异有统计学意义(P0.05)。与非肺损伤组比较，肺损伤组细胞因子含量均较高，差异有统计学意义(P0.05)。结论IL-6、IL-8及TNF-a的急剧增加可成为患者疾病严重很好的示警因子。 【关键词】急性主动脉夹层；急性肺损伤；细胞因子 Analysis of the changes of cytokine on acute aortic dissection with acute lung injury LI Ming，FA Xian′en , YANG Jingxue , ZHAO Genshang , WANG Hongshan , WANG Han，HANG Zhenfeng Cardiovascular Surgery of the Second Affiliated Hospital of Zhengzhou University , Zhengzhou ,450014 Abstract Aim To identify the the relationship between cytokine changes of acute aortic dissection with acute lung injury. Methods The 37 patients who admitted of acute aortic dissection of Cardiovascular Surgery of the Second Affiliated Hospital of Zhengzhou University From July 2010 to December 2013. They were divided into the group of with acute lung injury and without acute lung injury according prognosis. The control group was created with 20 healthy people． At the time of admission, IL-6, IL-8, TNF-a content in plasma from patients were measured between the groups . Results The concentration of IL-6、IL-8 and TNF-a in group without acute lung injury was significantly lower than the group with acute lung injury（P0.05）. The concentration of IL-6、IL-8 and TNF-a in acute aortic dissection group was significantly higher than the health group（P0.05）. Conclusion Dramatic increase of IL-6 、IL-8 and TNF-a can be factors of poor prognosis in patients of acute aortic dissection. Key Words Acute aortic dissection, acute lung injury, cytokine 第一作者：李明，男，汉族，1979年4月出生 ，医学博士，主治医师，河南省卫生科技创新人才，研究方向：心血管外科的临床研究，电话邮箱：417167346@。 *通讯作者：法宪恩，男，回族，1962年8月出生，中共党员，医学博士，主任医师，研究方向：心血管外科的临床研究，E-mail：faxianen@163.com。 河南省卫生科技创新人才工程项目资助 河南省医学学术技术带头人出国培训计划项目（201201053）。 急性肺损伤是急性主动脉夹层常见的严重并发症，可以直接影