ppt课件-systemicdiseaseandtheeye-internationalcouncilof.pptVIP

BEH?ET’S DISEASE Idiopathic multisystem disease More common in men Occurs in 3rd - 4th decade Highest incidence in Mediterranean region and Japan Associated with HLA-B5 BEH?ET’S DISEASEAetiology Unknown Various bacteria and viruses suggested No good evidence to suggest any of them Perpetuated by autoimmune response and CD4 + T-cells Tumour necrosis factor (TNF) thought to be important BEH?ET’S DISEASE Systemic Involvement (1) Oral aphthous ulceration – 100% BEH?ET’S DISEASE Systemic Involvement (2) Genital ulceration – 90% BEH?ET’S DISEASE Systemic Involvement (3) Skin lesions