《阿立哌唑替代利培酮和替代喹硫平治疗精神分裂症的疗效观察.docVIP

阿立哌唑替代利培酮和替代喹硫平治疗精神分裂症的疗效观察 林德颖 张晓东 【摘要】 目的：研究阿立哌唑、利培酮、喹硫平三者对精神分裂症的疗效以及不良反应。阿立哌唑替代利培酮和替代喹硫平治疗精神分裂症的疗效及安全性。方法：将123例经利培酮治疗的精神分裂症病人换用阿立哌唑治疗，将136例经喹硫平治疗的精神分裂症病人换用阿立哌唑治疗。换用阿立哌唑单独治疗精神分裂症时间超过半年。采用简明精神病量表（BPRS），治疗中出现的症状量表（TESS）评定。监测化验血清催乳素（PRL）水平。结果：阿立哌唑、利培酮、喹硫平三者对精神分裂症的疗效相当，但是利培酮和喹硫平导致体重增加、高催乳素（PRL）血症的副作用明显，使病人和家属依从性差，而阿立哌唑替代二者治疗后病人的体重明显恢复，血清催乳素（PRL）水平也恢复正常，乳腺增生、泌乳以及月经量减少或者闭经症状消失，月经恢复正常。结论：阿立哌唑替代利培酮和替代喹硫平治疗精神分裂症的疗效确切，安全性更高，完全可以取代二者治疗精神分裂症。阿立哌唑治疗精神分裂症的前景更加广泛。 【关键词】 阿立哌唑 利培酮 喹硫平 精神分裂症 催乳素 体重 Objective: to study the aripiprazole, risperdal, quetiapine three to the curative effect of schizophrenia and adverse reactions. Aripiprazole alternative risperdal and alternative quetiapine treat schizophrenia safety and efficacy. Methods: 123 patients with the risperdal treatment of patients with schizophrenia, change with aripiprazole treatment, 136 patients with quetiapine treatment of patients with schizophrenia, change with aripiprazole treatment. Change with aripiprazole separate treat schizophrenia time more than half a year. The brief psychiatric scale (BPRS), appear in the treatment emergent symptoms scale (TESS). Monitoring tests serum prolactin (PRL) level. Results: aripiprazole, risperdal, quetiapine three to the curative effect of schizophrenia, but quite risperdal and quetiapine lead to weight gain, high prolactin (PRL) the side effects of the disease, make clear the patient and family compliance bad, and aripiprazole alternative treatment of patients after both weight markedly, serum prolactin (PRL) level also back to normal, mammary gland hyperplasia, lactation and menstrual quantity to reduce or menopause symptoms disappeared, menstruation is back to normal. Conclusion: aripiprazole alternative risperdal and alternative quetiapine treat schizophrenia symptoms, and safety, and can completely replace higher both treat schizophrenia. Aripiprazole treat schizophrenia and more extensive prospect. 【 key words 】 aripiprazole risperdal quetiapine schizophrenia