tocilizumabguidelinesforadultpatientsbasedontheagreetool.docVIP

GUIDELINES FOR THE USE OF INTRAVENOUS TOCILIZUMAB IN THE TREATMENT OF ADULT PATIENTS WITH RHEUMATOID ARTHRITIS SCOPE AND PURPOSE Background Rheumatoid arthritis (RA) is a chronic multi-system inflammatory disorder with a prevalence of 0.5-1% in the general population. The management of RA has evolved considerably in the last few decades and newer therapies continue to be developed. Tocilizumab (TCZ)(1) is a humanised anti interleukin-6 receptor (anti IL-6R) antibody licensed for use in combination with methotrexate (MTX) for the treatment of moderate to severe RA in adult patients who have e