醋酸棉酚对白血病hl.docVIP

醋酸棉酚对白血病HL 【关键词】 细胞凋亡 Effects of gossypol acetic acid on apoptosis and differentiation in leukemia HL60 cells 　　【Abstract】 AIM: To investigate the effects of gossypol acetic acid(GAA) on apoptosis and differentiation in classic human actue promylocytic leukemia cell line HL60 and study the possibility to treat leukemia with it. METHODS: The cytotoxic activity of GAA on HL60 cells was detected by means of MTT assay. Apoptosis was identified and analyzed with the help of transmission electron microscopy, cell cycle, and DNA gel electrophoresis, etc.