incorporating uncertainty in distance-matrix phylogenetics.pptVIP

Incorporating uncertainty in distance-matrix phylogenetics Distance-based methods Larger trees Faster algorithms Less model-dependent Genome-scale evolutionary rearrangements Agglomerative distance methods NJ (Saitou and Nei, 1987) BioNJ (Gascuel, 1997) Weighbor (Bruno et al, 2000) MVR (Gascuel, 2000) FastME (Desper and Gascuel, 2004) Variance models Independent distances Ordinary Least Squares (OLS) Weighted Least Squares (WLS) NJ, Weighbor, FastME Correlated distances shared evolutionary paths (Chakraborty, 1977) computed from shared sequences: BioNJ induced by estimation process (we show) G