高原地区阿尔茨海默病患者高同型半胱氨酸水平的变化和干预治疗效果研究(核心).docVIP

高原地区阿尔茨海默病患者高同型半胱氨酸水平的变化和干预治疗效果研究 【摘要】目的 探究高原地区阿尔茨海默病（AD）患者高同型半胱氨酸（Hcy）水平的变化和干预治疗效。方法 随机选取于2012年6月至2014年6月前来我院接受治疗的45例来自高原地区（平均海拔2350m）的阿尔茨海默病患者作为本次研究实验观察组对象，另取32例正常健康老年人作为对照组，测定患者治疗前后和健康正常人血清内Hcy、叶酸和维生素B12含量，分析比较。结果 观察组患者入院时Hcy、叶酸和维生素B12含量不在正常范围内，与健康正常人相比均有显著性差异（P0.05）。观察组患者治疗后MMSE得分上升较多，治疗前后比较有统计学意义（u=6.2780，P=0.000）；同时ADL评分下降，治疗前后比较有统计学意义（P0.05）。观察组患者入院时Hcy、叶酸和维生素B12含量不在正常范围内，治疗后有较大变化，各项指标含量治疗前后比较有统计学意义（P0.05）。结论 高原地区阿尔茨海默病（AD）患者高同型半胱氨酸（Hcy）水平有明显升高趋势，在使用叶酸和维生素B12相关药物干预治疗后，高同型半胱氨酸恢复正常，且患者认知功能障碍减轻同时独立活动能力增强，疗效较好，有利于患者提高生活质量。 【关键词】高海拔地区；阿尔茨海默病；高同型半胱氨酸；干预；疗效 Changes in patients with Alzheimer highlands homocysteine levels and intervention treatment study [Abstract]Objective To study the intervention effect of Alzheimers disease (AD) patients with high homocysteine (Hcy) levels and changes in the plateau region .Methods 45 cases of patients with Alzheimers disease (average altitude of 2350m) from June 2012 to June 2014 in our hospital were researched as the experimental group objects, another 32 cases of normal healthy elderly control group,measured before and after treatment and the health of normal human serum Hcy, folic acid and vitamin B12 content, analysis and comparison..Results Hcy, folate and vitamin B12 content is not in the normal range, compared with healthy controls showed significant differences (P 0.05) was observed in patients during hospitalization. After the observation group patients MMSE scores rise more, comparing before and after treatment was statistically significant (u = 6.2780, P = 0.000); while ADL score decreased compared before and after treatment was statistically significant (P 0.05). Hcy, folate and vitamin B12 content is not in the normal range, there are significant changes observed after treatment of patients admitted to hospital, were statistically significant indicators before and after treatment content (P 0.05).Conclusion Plateau Alzheimers disease (AD) patients with high homocysteine (Hcy) levels have significantly increased tre