胰岛素新剂型的研究与进展.docVIP

毕业设计报论文 —课题英文文献翻译 系 别： 制药与生物工程技术系 课题名称： 胰岛素新剂型的研究与进展 班 级： 化学制药技术 Research progress on insulin administration route for patients Abstract　For many years, insulin is administrated by subcutaneous injections to treat patients with diabetes. In order to enhance the medication compliance of diabetes patients, scholars of both abroad and at home go in for study on non injection way of administration and probe into an ideal administration route of insulin so as to enhance the therapeutic effect of insulin. Key words　insulin; dosage form; administration route Insulin (insulin, INS) is a peptide drugs to treat diabetes, since 1921, Banting and Best discovered for the first time in the clinical application of INS has been using subcutaneous injection. For decades, people in order to improve the efficacy of INS, INS formulations continuous improvement, constantly updated INS injection devices, but these methods are ultimately inseparable from the injection means. Therefore, application of non-injecting means INS has been an ideal way for people to explore. INS agents, including non-injecting means of lung inhalation,oral preparations, mucosal delivery formulations and trandermal delivery systems [1]. Due to many new technologies, to the INS, the application of non-injecting means a very good development. INS is now the present we reviewed the route of administration. 1 INS injection 1.1Subcutaneous injection Different parts of the INS be fast or slow absorption of subcutaneous abdominal injection absorbed the fastest, followed by upper arms, thighs, buttocks. INS also absorbed dose levels and physical activity, the greater the dose, the higher the concentration, slower absorption and absorption rate of movement will increase. Abdominal area, there are advantages of subcutaneous injection, usually the abdomen of adult-type arrangement for rotation or subcutaneous injection, as two distance 2 cm, ca