natural killer cell therapy【DOC精选】.docVIP

Prospects for adoptive natural killer cell therapy Abstract: Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes, involved in the immune defense against viral infections and tumors. Their effector function is regulated by cytokines and membrane associate receptors able to inhibit or activate cellular programs. NK cells are able to discriminate self from non-self through MHC class I-binding inhibitory receptor. When NK cells are faced with allogeneic targets which do not express the inhibiting class I ligand(s), NK cells may mediate alloreactions (“missing self” recogniti