Genetics and Parkinson’s disease遗传学与帕金森病.pptVIP

Genetics, environment and Parkinson’s disease Southern Neurology Epidemiology 1-2% of population over age 65 years 85% sporadic, 10-15% familial clustering and 5% monogenic inheritance Advancing age is important risk factor Twin studies report similar concordance of 10-20% for monozygotic and dizogtic twins. Limitations of epidemiological studies in familial cases Clinical manifestations may not develop in pre-symptomatic sibling for a number of years Duration and time to follow-up important Aetiology is very likely a complex mixture of environmental and genetic factors. Environmental factors