单中心179例肾活检临床病理分析.docVIP

单中心179例肾活检临床病理分析 　　【摘要】 目的：探讨单中心近3年179例肾活检患者肾脏疾病流行病学特点、不同年龄段肾脏疾病构成比的特点。方法：回顾性分析单中心179例行肾活检者的年龄、病理类型及临床表现等相关资料。结果：原发性肾小球疾病仍为目前最主要的肾脏疾病（78.77%）。膜性肾病是最常见的原发性肾小球疾病（31.91%）。各年龄段原发性肾小球肾炎和继发性肾小球炎的构成比比较差异有统计学意义（P0.001）。44.44%的膜性肾病患者年龄位于18～44岁，微小病变好发于18～44岁，而65岁以上患者最常见为膜性肾病（57.14%）。18岁以下最常见的继发性肾小球肾炎为紫癜性肾炎（50.00%），18～44岁最常见的继发性肾小球肾炎是狼疮性肾炎（38.89%）。结论：原发性和继发性肾小球肾炎构成比均随年龄变化，不同年龄肾炎患者构成比各有特点。 　　【关键词】 肾活检； 肾小球肾炎； 膜性肾病； 继发性肾小球肾炎 　　中图分类号 R692 文献标识码 B 文章编号 1674-6805（2015）18-0060-03 　　Clinic and Pathological Analysis of 179 Cases on Percutaneous Renal Biopsy from A Single Center/WANG Li-hua，NI Li-jun，XU Ao.//Chinese and Foreign Medical Research，2015，13（18）：60-62 　　【Abstract】 Objective：To retrospectively study 179 cases of native kidney biopsies from a single center in three years and to identify the epidemiological characters and age-specific pathological features.Method：The features of clinical data，age and types of pathology of 179 native kidney biopsies in single center were retrospectively analyzed.Result：Primary glomerulonephritis remained the most common pathologic pattern account for 78.77%.The most common type of primary glumerulonephritis was membranous nephropathy account for 31.91%.There were statistical significant in an age-specific impact on the constitution of primary glomerulonephritis and secondary glomerulonephritis（P0.001）.The most common membranous nephropathy was between 18-44 years old account for 44.44%.Patients between 18-44 years old were mainly focal minimal changes diseases.Patients aged more than 65 years were mainly focal membranous nephropathy（57.14%）.The most common secondary kidney disease was Henoch-Schonlein Purpura Nephritis（50.00%） under 18 years old.Lupus nephritis was the most common（38.89%） in 18-44 years old.Conclusion：The pathologic patterns of primary glomerulonephritis and secondary glomerulonephritis varied yearly with age specific characteristics. 　　【Key words】 Renal biopsy； Primary glomerulonephritis； Membranous nephropathy； Secon