综合护理干预对化疗联合TACE治疗胃癌伴肝转移患者毒副反应的影响.docVIP

综合护理干预对化疗联合TACE治疗胃癌伴肝转移患者毒副反应的影响 　　[摘要] 目的 探讨护理干预对化疗联合TACE治疗胃癌伴肝转移患者的毒副反应的影响。 方法 选取2012年1月～2014年10月我院胃肠外科收治的胃癌伴肝转移的患者52例，均行化疗及TACE治疗。采用随机数字表法及随机数余数分组法将患者分成观察组（26例）和对照组（26例），观察组予护理干预，对照组行常规护理。比较两组毒副反应发生的情况，评价护理干预对降低毒副反应发生的影响。 结果 经过护理干预，观察组患者的SDS评分与SAS评分显著低于对照组（P0.05），胃肠道反应、口腔黏膜病变总的发生率均明显低于对照组（P0.05）。同时发现Ⅱ～Ⅳ级的胃肠道反应、口腔黏膜病变、骨髓抑制反应（白细胞减少）、周围神经毒性反应及皮肤毒性的比率观察组均低于对照组（P0.05）。 结论 对化疗联合TACE治疗胃癌伴肝转移的患者实施早期有效的护理干预，能使患者对治疗的毒副反应有正确的认识和心理准备，减轻患者负性情绪，减少一些毒副反应的发生率，能提高患者对化疗的依从性及治疗的信心，达到最佳的治疗效果。 　　[关键词] 胃癌伴肝转移；化疗；TACE；护理干预；毒副反应 　　[中图分类号] R473.6 [文献标识码] B [文章编号] 1673-9701（2016）09-0135-05 　　[Abstract] Objective To explore the effect of nursing intervention on the side effect of chemotherapy combined with TACE in treatment of gastric cancer with liver metastasis. Methods Fifty two gastric cancer with liver metastasis cases， who accepted not only chemotherapy but TACE were included from January 2012 to October 2014 Gastrointestinal Surgery in our hospital. All patients were divided into observation group（26 cases） and control group（26 cases） by random number table method. The former received nursing intervention and the later received routine nursing care. The adverse reactions and the effects of nursing measures to reduce the toxicities were evaluated in both groups. Results After nursing intervention， the SDS and SAS scores of observation group were significantly lower than those of control group（P0.05）. In the observation group， the incidences of gastrointestinal reaction and oral mucosal lesion were significantly lower than those in the control group（P0.05）. What’s more， the ratios of grade Ⅱ-Ⅳ of gastrointestinal reaction， oral mucosal lesion， bone suppression （leukopenia）， peripheral neuropathy and dermal toxicity were similarly lower in former than those in the later（P0.05）. Conclusion The gastric cancer with liver metastasis patients， treated with chemotherapy combined with TACE， will have a correct understanding and mental prepare of adverse reaction， if they are nursing i