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examplesinbookstatisticalmethodsindiagnosticmedicine.doc

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examplesinbookstatisticalmethodsindiagnosticmedicine

Examples in book Statistical Methods in Diagnostic Medicine by Xiao-hua Zhou et.al. Chapter 4 (1) roc.binary(s1, s0, r1, r0, alpha) DESCRIPTION: Function roc.binary estimate the sensitivity, specificity and their variances for the binary data. Two types of confidence intervals are calculated, namely asymptotic C.I. and score C.I. The description is on the 104 of the book. USAGE: s1: number of subjects with D=1 and T=1 s0: number of subjects with D=1 and T=0 r1: number of subjects with D=0 and T=1 r0: number of subjects with D=0 and T=0 alpha: significance level, (1-alpha)% C.I. are reported EXAMPLE: Mammogram results of 30 pts with and 30 patients without breast cancer, on page 17 of the book. roc.binary(29, 1, 19, 11, 0.05) $estimate [,1] se 0.9666667 sp 0.3666667 $variance [,1] se.var 0.001074074 sp.var 0.007740741 $asympCI [,1] [,2] se.asympCI 0.9024326 1.0309007 sp.asympCI 0.1942261 0.5391072 $scoreCI [,1] [,2] se.scoreCI 0.8332961 0.9940914 sp.scoreCI 0.2187392 0.5448644 (2) roc.ordinal.emp(data, alpha) DESCRIPTION: Fitting an empirical ROC curve for ordinal data, plot the empirical curve and calculate the area under the empirical curve and its variance. The variance is calculated by 2 methods—Hanley McNeil, Delong and Delong Clarke-Pearson. Two types of C.I. are given consequently. Methods are on 118 of the book USEAGE: roc.ordinal.emp(data, alpha) data: dimension of data is 2 x K . The first row is D=1 and the second row is D=0. The column is the counts of categories of 1 to K( ordinal scale) alpha: significance level, (1-alpha)% C.I. are reported EXAMPLE: Workstation-displayed digitized-film mammogram. Table 4.6 on page 111 roc.ordinal.emp(data, 0.05) $area.empROC [1] 0.8470085 $var.empROC.HM [1] 0.005043847 $var.empROC.DDC [1] 0.003584896 $empROC.CI.HM [1] 0.7078118 0.9862053 $empROC.CI.DDC [1] 0.7078118 0.9862053 (3) roc.

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