NAVIGATOR研究设计、结果及意义.pptVIP

* * * 基础研究证实，血管紧张素II具有激活前突触和后突触RAS及SNS的作用。而ARB具有独特的双重抑制RAS及SNS激活作用，同时抑制RAS和交感活性，改善胰岛素敏感性。 the presence of any three of the following five features is defined as metabolic syndrome: (i) abdominal obesity (waist circumference ≥ 90 cm in men and ≥ 80 cm in women); (ii) elevated triglycerides (≥ 1.70 mmol/l), or drug treatment for elevated triglycerides; (iii) reduced HDL cholesterol ( 1.04 mmol/l in men and 1.30 mmol/l in women), or drug treatment for reduced HDL cholesterol; (iv) elevated blood pressure (≥ 130 mmHg for systolic or ≥ 85 mmHg for diastolic), or antihypertensive drug treatment in