中医疗法与透明质酸治疗膝骨性关节炎有效性的网状Meta课程.doc

中医疗法与透明质酸治疗膝骨性关节炎有效性的网状Meta分析 刘 羽1，艾金伟1，2，刘 盈2，李德胜1，裴 斌1，2(湖北医药学院附属襄阳医院，1整形外科，2循证医学中心，湖北省襄阳市 441000) 引用本文：刘羽，艾金伟，刘盈，李德胜，裴斌.中医疗法与透明质酸治疗膝骨性关节炎有效性的网状Meta分析[J].中国组织工程研究，2016，20(20):3000-3011. DOI: 10.3969/j.issn.2095-4344.2016.20.016 ORCID: 0000-0002-4380-4266(刘羽) 文章快速阅读： 文题释义： 网状Meta分析透明质酸Efficacy of traditional Chinese medicine therapy and hyaluronic acid for knee osteoarthritis: a network Meta-analysis Liu Yu1, Ai Jin-wei1, 2, Liu Ying2, Li De-sheng1, Pei Bin1, 2 (1Department of Plastic Surgery; 2Evidence-Based Medicine Center, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, Hubei Province, China) Abstract BACKGROUND: Comparative study results between the efficacies of traditional Chinese medicine (TCM) therapy with Western medicine therapy in the treatment of knee osteoarthritis remain controversial. Currently, meta-analysis studies mainly focus on comparison of the efficacy between TCM and Western medicine, but lack investigations among TCM therapies. It makes us difficult to fully understand the efficacy of TCM therapy for knee osteoarthritis. OBJECTIVE: To compare the efficacies of TCM therapy with intra-articular injection of hyaluronic acid for knee osteoarthritis using a network Meta-analysis method. METHODS: PubMed, The Cochrane Library (tissue 10, 2015), EMbase, CNKI, CBM, VIP, Wangfang databases were searched up to October 20, 2015 for relevant randomized controlled trials addressing the efficacies of TCM therapy versus intra-articular injection of hyaluronic acid for knee osteoarthritis. Two reviewers independently selected the studies, extracted information, and assessed the quality of included trials. Data extraction from eligible studies was pooled and meta-analyzed using Stata12.0 and WinBUGS1.4.3 softwares. Odd ratios with their 95% confidence interval were estimated as effect size between treatments. RESULTS AND CONCLUSION: A total of 59 randomized controlled trials involving 6 155 patien