WatsonCrick论文粗译(英汉对照含图).docVIP

Nature VOL 171, page737. 2 April 1953 A Structure for Deoxyribose Nucleic Acid 脱氧核糖核苷酸的结构 We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest. A structure for nucleic acid has already been proposed by Pauling and Corey (1). They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fibre axis, and the bases on the outside. 我们想推测出DNA结晶的结构。这些结构有许多新的为很多生物学家所吸引的特点.Pauling and Corey已经提出过核苷酸的一个结构.他们在出版以前慷慨的把他们的手稿给我们看过。他们的模型由三条相互缠绕的链组成，磷酸基团靠近中心轴，而碱基在外面。 In our opinion, this structure is unsatisfactory for two reasons: 我们认为，这个模型有以下两个方面的不足 (1) We believe that the material which gives the X-ray diagrams is the salt, not the free acid. Without the acidic hydrogen atoms it is not clear what forces would hold the structure together, especially as the negatively charged phosphates near the axis will repel each other. (2) Some of the van der Waals distances appear to be too small. 1.我们相信是晶体这个材料产生的X-衍射图标，而不是自由的酸。如果没有酸性的氢原子就不能确定什么使这些结构结合在一起。2.一些范德华距离太小 Another three-chain structure has also been suggested by Fraser (in the press). In his model the phosphates are on the outside and the bases on the inside, linked together by hydrogen bonds. This structure as described is rather ill-defined, and for this reason we shall not comment on it. Fraser（在出版社里）曾提出过另一个三链的结构模型。在他的模型中磷酸基团在外面，碱基在里面，他们以氢键连接曾被描述为相当不好的定义，因此我们在这不做评论。 We wish to put forward a radically different structure for the salt of deoxyribose nucleic acid. This structure has two helical chains each coiled round the same axis (see diagram). We have made the usual chemical assumptions, namely, that each chain consists of phosphate diester groups joining ?-D-deoxyribofuranose residues with 3,5 linkages. 我们想提出一个根本不同的脱氧核糖核苷酸晶体的结构。这一结构有两条螺旋的链，每条绕着同一中心轴盘绕（如图所示）。我们曾做过普通的化学假定，换句话说，每条链由在3’,5处将磷酸二酯基团加入到脱氧核呋喃糖中。 The two cha