差异含氧量下的运动对心肌细胞代谢水平影响.pdfVIP

差异含氧量下的运动对心肌细胞代谢水平影响 李 静 （川北医学院组胚教研室，四川南充 637007） 摘 要：目的：分析差异含氧量下运动对心肌细胞代谢水平的影响 方法：以大鼠不运动、高含氧运动 训练、低含氧运动训练为运动模型，在训练前、后分别观察大鼠的情况，并检测其体重、心脏重量以及心 系数的变化，用MDA和SOD试剂盒测试心肌组织中MDA含量和SOD活性，分析差异含氧量运动对大 鼠心肌组织中脂质过氧化水平的影响 结果:同对照组大鼠对比，高含氧训练组大鼠体重降低（P 0.01）,心脏重量和心系数增加（P0.01），同对照组大鼠对比，低含氧训练组大鼠体重明显降低，心脏重 量和心系数都显著提高（P0.01）；同对照组对比，高含氧训练组LVSP、dp/dt max显著性下降（都是P 0.01），LVEDP则显著性升高（P 0.01）；同高含氧训练组对比，低含氧训练组LVSP、dp/dt max显著性升 高（都是P0.01），LVEDP则显著性下降，低含氧运动训练可造成大鼠心肌细胞中MDA含量明显增加, SOD活性显著下降(P0.01),高含氧运动训练未见大鼠心肌细胞MDA含量和SOD活性的显著变化 结 论:低含氧运动造成的心肌细胞脂质过氧化水平降低,是过度训练引起心肌细胞代谢降低的机制之一 关键词：含氧量；运动；心肌；细胞；代谢影响 中图分类号：R44 文献标识码：A 文章编号：1001 7119（2014）03 0061 03 Movement Effect on Myocardial Cell Metabolism Under Differences Oxygen Content Li Jing （North Sichuan Medical University，Sichuan Nanchong 637007，China） Abstract：Objective:to analyse movement effects on myocardial cell metabolism under differences oxygen content. Methods: the rat dont exercise, the high oxygen, low oxygen exercise training in sports training model for the motion, the training of rats were observed before and after, and detect the changes in body weight, heart weight and coefficient, using MDA and SOD kit test, MDA content and SOD activity in myocardial tissue oxygen movement analysis of differences between the myocardial tissue of rat in the influence of the level of lipid peroxidation. Results: rats compared with control group, the high oxygen rats weight reducing exercise group (P0.01), the heart and heart weight coefficient increased (P0.01), the rats compared with control group, low oxygen training rats significantly lower body weight, heart and heart weight coefficient were significantly increased (P0.01); Compared with the control group, high oxygen training group LVSP, dp/dt Max significantly decreased (all P0.01), elevated LVEDP were significant (P0.01); Contrast with high oxygen training group, low oxygen LVSP, dp/dt Max exercise group are significantly higher (P0.01), LVEDP were significantly decreased, the low oxygen exercise tra