Expressionandcorrelationofsodiumiodidesymporterandthyroid.docVIP

Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma autori - vau_aut_id Zhi-Feng Wang1, Qin-Jiang Liu2, Shi-Qi Liao3, Rong Yang4, Ting Ge3, Xin He4, Cai-Ping Tian3, and Wei Liu4 affiliazione_autori - ignora 1Institute of Cell Biology, College of Life Sciences, Lanzhou University, Lanzhou Gansu; 2Department of Head and Neck Surgery, 3Molecular Biology Center, and 4Department of Pathology, Gansu Tumor Hospital, Lanzhou Gansu, China keyword - vke_key_id Key words:?sodium/iodide symporter, thyroid stimulating hormone receptor, thyroid carcinoma. affiliazione_autori - ignora Acknowledgments: This work was supported by the Gansu Science and Technology support program (No. 0804NKCA087). We thank the doctors and nurses of the department of head and neck surgery and the operating room in Gansu Tumor Hospital for their generous assistance. Correspondence to:?Qin-Jiang Liu, Gansu Tumor Hospital, Xiaoxihu ES, Lanzhou, 730050 Gansu, PR China. Tel +86-931-2614521-2010; fax +86-931-2614551; e-mail LIUQJ99@ Received August 30, 2010; accepted December 6, 2010. riassunto - art_riassunto abstract Aims. To investigate the expression of sodium/iodide symporter (NIS) and thyroid stimulating hormone receptor (TSHR) in human thyroid cancer.? Patients and methods. NIS and TSHR mRNA levels quantified by real-time PCR as well as NIS and TSHR proteins evaluated by immunohistochemistry were examined in surgical specimens including 38 benign nodules, 32 thyroid carcinomas and 36 normal thyroid samples. Results. NIS and TSHR mRNA levels in thyroid carcinomas were significantly lower than in benign nodules and normal thyroid samples (P 0.001). Interestingly, we found that NIS and TSHR mRNA expression in benign nodules had similar levels to those in normal thyroid tissues. However, NIS and TSHR protein expression in benign nodules and thyroid carcinomas was stronger than in normal thyroid samples (P 0.05) but mainly lo