LymphocyteMigrationDr.ColinR.A.Hewittcrah1@le.ac.uk.pptVIP

Lymphocyte Migration ?Dr. Colin R.A. Hewitt crah1@le.ac.uk;Homing to lymph node;Patterns of lymphocyte trafficking Na?ve T cells;Post capillary venules in 2o lymphoid tissue HIGH ENDOTHELIAL VENULES. Specialised to allow lymphocytes and nothing else into the lymph node;Role of endothelial cells in trafficking and recirculation;The multi-step paradigm of leukocyte migration: Step 1: Tethering rolling;SELECTINS Leucocytes inc. Naive T cells: L SELECTIN Endothelial cells: P SELECTIN E SELECTIN P selectin: Weibel-Palade bodies. E selectin: TNF IL-1 induced A common core with different extrac