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Formation mechanism of colloidal nanoparticles obtained from probucol-PVP-SDS ternary ground mixture.pdf

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Formation mechanism of colloidal nanoparticles obtained from probucol-PVP-SDS ternary ground mixture

A( a s c 1 1 c G P t ? K 1 c t d n L t s a t o w 0 dAvailable online at International Journal of Pharmaceutics 352 (2008) 309–316 Pharmaceutical Nanotechnology Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture Adchara Pongpeerapat a, Chalermphon Wanawongthai a, Yuichi Tozuka b, Kunikazu Moribe a, Keiji Yamamoto a,? a Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan b Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502-8585, Japan Received 13 August 2007; received in revised form 21 September 2007; accepted 29 October 2007 Available online 26 December 2007 bstract The purpose of this study was to investigate the formation mechanism of colloidal nanoparticles after dispersion of probucol/polyvinylpyrrolidone PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture (GM) into water. Probucol, PVP and SDS were mixed at a weight ratio of 1:3:1 nd ground for 30 min with a vibrational rod mill. The morphology and physicochemical properties were investigated through high resolution canning electron microscopy (SEM), environmental SEM, dynamic light scattering, 13C NMR and zeta potential measurements. SEM images onfirmed the presence of 20 nm size primary particles in the GM powder of probucol/PVP K17/SDS. Spherical nanoparticles with a size of around 00 nm, formed after dispersion of the GM into water, suggested an agglomeration of the primary particles. A further agglomeration of around 60 nm was observed with the stability experiment. Zeta potential and particle size measurements using latex beads revealed that PVPK 17/SDS omplex was adsorbed on the probucol particle surface forming a layered structure. A similar agglomeration behavior was observed using the M of probucol/PVP K12/SDS, though the molecular state of the PVPK 12/SDS complex at the particle surface was different from that of the VPK 17/SDS complex. 13C NMR results suggested that inter