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Mechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF.pdf

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Mechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF

Biochemical and Biophysical Research Communications 410 (2011) 62–67Contents lists available at ScienceDirect Biochemical and Biophysical Research Communications journal homepage: www.elsevier .com/locate /ybbrcMechanical stretch of sympathetic neurons induces VEGF expression via a NGF and CNTF signaling pathway Erol Saygili a,?,1, Maimouna Pekassa a,1, Esra Saygili a, Gediminas Rackauskas a,b, Dorothee Hommes a, Fawad Noor-Ebad a, Christopher Gemein a, Matthias D.H. Zink a, Robert H.G. Schwinger c, Joachim Weis d, Nikolaus Marx a, Patrick Schauerte a, Obaida R. Rana a aDepartment of Cardiology, University RWTH Aachen, Aachen, Germany bDepartment of Cardiology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania cMedical Clinic II, Klinikum Weiden, Weiden, Germany d Institute for Neuropathology, University RWTH Aachen, Aachen, Germany a r t i c l e i n f o a b s t r a c tArticle history: Received 16 May 2011 Available online 24 May 2011 Keywords: Mechanical stretch Sympathetic neurons VEGF NGF HIF-1a KDR0006-291X/$ - see front matter 2011 Elsevier Inc. A doi:10.1016/j.bbrc.2011.05.105 Abbreviations: NGF, nerve growth factor; NT-3, neu derived neurotrophic factor; CNTF, ciliary neurotrophi receptor A; VEGF, vascular endothelial growth factor 1a, hypoxia-inducible factor-1 alpha; SCG, superior thetic neurons; MI, myocardial infraction. ? Corresponding author. Address: Department of C Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany. F E-mail address: esaygili@ukaachen.de (E. Saygili). 1 These authors contributed equally to this work.Mechanical stretch has been shown to increase vascular endothelial growth factor (VEGF) expression in cultured myocytes. Sympathetic neurons (SN) also possess the ability to express and secrete VEGF, which is mediated by the NGF/TrkA signaling pathway. Recently, we demonstrated that SN respond to stretch with an upregulation of nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF). Whether stretch increases neu