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Predictorsofmortalityinα1-antitrypsindeficiency.ppt
Predictors of mortality in α1-antitrypsin deficiency by P A Dawkins, L J Dowson, P J Guest, and R A Stockley Thorax Volume 58(12):1020-1026 November 26, 2003 Copyright ? BMJ Publishing Group Ltd British Thoracic Society. All rights reserved. Kaplan-Meier all cause survival plot for all PiZ patients on assessment programme (0 years, n?=?256; 1 year, n?=?208; 2 years, n?=?118; 3 years, n?=?75; 4 years, n?=?42). P A Dawkins et al. Thorax 2003;58:1020-1026 Copyright ? BMJ Publishing Group Ltd British Thoracic Society. All rights reserved. Scatter graphs for (A) forced expiratory volume in 1 second (FEV1) % predicted (n?=?248), (B) carbon monoxide transfer coefficient (Kco) % predicted (n?=?249), (C) upper expiratory scan voxel index (n?=?196), (D) St George’s Respiratory Questionnaire activity scores (n?=?255) in survivors, all-cause deaths, and respiratory deaths for all patients assessed in the programme. P A Dawkins et al. Thorax 2003;58:1020-1026 Copyright ? BMJ Publishing Group Ltd British Thoracic Society. All rights reserved. Kaplan-Meier plots showing respiratory deaths for the 170 patients entered into the Cox survival analysis, stratified into tertiles for (A) FEV1 % predicted (A?=?63.8%, B?=?37.5–63.8%, C?=?37.5%); (B) Kco % predicted (A?=?80.0%, B?=?57.8–80.0%, C?=?57.8%); (C) CT scan voxel index (upper expiratory view) (A?=?8.1, B?=?8.1–27.8, C?=?27.8); and (D) SGRQ activity scores (A?=?53.4, B?=?53.4–83.0, C?=?83.0). P A Dawkins et al. Thorax 2003;58:1020-1026 Copyright ? BMJ Publishing Group Ltd British Thoracic Society. All rights reserved. Kaplan-Meier all cause survival plot for all PiZ patients on assessment programme (0 years, n?=?256; 1 year, n?=?208; 2 years, n?=?118; 3 years, n?=?75; 4 years, n?=?42). Mortality rate?=?~4% per year. Scatter graphs for (A) forced expiratory volume in 1 second (FEV1) % predicted (n?=?248), (B) carbon monoxide transfer coefficient (Kco) % predicted (n?=?249), (C) upper expiratory scan voxel index (n?=?196), (D)
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