利用ROC曲线评价CEACA153在HER-2阳性乳腺癌术后随访中的价值.docVIP

利用ROC曲线评价CEA、CA153在HER-2阳性乳腺癌术后随访中的价值 侯军君1 任立瑾2 高媛媛1 刘潇莲1 蔡莉1 【摘要】 目的 用ROC曲线评价CEA及CA153监测HER-2阳性乳腺癌患者术后复发转移的价值，并确立诊断HER-2阳性乳腺癌患者术后复发转移的最佳临界值。方法 收集127例HER-2阳性乳腺癌患者CEA及CA153数值，将其分为复发转移及未复发转移两组。绘制ROC曲线，找到最佳临界值，同时比较最佳临界值与常规诊断值诊断复发转移的优劣。结果 复发转移组较未复发转移组CEA及CA153水平显著偏高（P 0.0001），CEA、CA153诊断复发转移ROC曲线下面积分别为0.752、0.820，对应的最佳临界值分别为3.5ng/ml、17.89U/ml。CEA和CA153最佳临界值敏感性分别为46.15%、65.38%，CEA和CA153最佳临界值特异性分别为97.33%、89.33%。结论 CEA、CA153在HER-2阳性乳腺癌患者术后随访中价值中等，诊断术后复发转移的最佳临界值分别为3.5ng/ml、17.89U/ml。 【关键词】：乳腺癌；癌胚抗原；CA153；ROC曲线 【中图分类号】R 737.9 【文献标识码】A Evaluating the value of CEA and CA153 during follow-up in HER-2 overexpressing breast cancer using ROC curves HOU Junjun1 REN Lijin2 GAO Yuanyuan1 LIU Xiaolian1 CAI Li1 1Harbin medical university affiliated tumor hospital, Heilongjiang 150081,2Heilongjiang University of Chinese Medicine 【Abstract】 Objective To explore the value?of carcinoembryonic antigen (CEA) and?cancer?antigen?153?(CA?153) in detecting tumor recurrences and to establish the optimal operating point of diagnosis of recurrences in HER-2 overexpressing breast cancer using ROC curves. Methods A total of 127 HER-2 overexpressing breast cancer patients was enrolled into this study and subdivided into two groups, the recurrence group and the non- recurrence group. We created a ROC curve and found out the optimal operating point. Then we compared the advantage of detecting recurrences between optimal operating point in the ROC curve and the diagnostic point that we usually used. Results The recurrence groups showed significantly higher CEA and CA153 levels than the non- recurrence groups（P 0.0001）. The area under the curve (AUC) of the CEA and CA153 were 0.752 and 0.820 respectively and the optimal operating point were 3.5ng/ml and 17.89U/ml, respectively. The sensitivities of the optimal operating point of CEA and CA153 were 46.15% and 65.38% respectively, and the specificities were 97.33% and 89.33%, respectively. Conclusions CEA and CA153 process medium value for detectin