甲状腺激素在心脏重塑中的前景幻灯片.pptxVIP

New insights into the role of thyroid hormone in cardiacremodeling: time to reconsider?;Backgrounds;3.nature’s paradigms of tissue remodeling/regeneration---- 两栖动物变态;4.TH has attracted little attention in the context of cardiac disease;content;一 . Cardiac remodeling;二. Thyroid hormone ;甲状腺激素;Two TR genes, α and β, encode four T3-binding receptor isoforms (α1, β1, β2, and β3); The distinct function of TR isoforms has been identi?ed;3.TRα 1 function in heart ;a fetal transcriptional gene re-programming;TRa1: a molecular switch to the fetal phenotype;mechanisms of altered TRa1 exp