CHEST 中文版.pdf

CHEST 中文版 文　摘 月经周期中呼出气一氧化氮与雌激素和 孕激素的相关性研究 Piush J. Mandhane, MD, PhD; Steven E. Hanna, PhD;Mark D. Inman, MD, PhD; Joanne M. Duncan, BSc; Justina M. Greene, Dip Comp Sys; Hong-Yu Wang, MD, PhD; and Malcolm R. Sears, MB From the Firestone Institute for Respiratory Health (Drs. Mandhane, Inman, Wang, and Sears, Ms. Duncan, and Ms. Green), St. Joseph’s Healthcare, Hamilton, ON, Canada; the Department of Medicine (Drs. Mandhane, Inman, Wang, and Sears, Ms. Duncan, and Ms. Green), and the Department of Clinical Epidemiology and Biostatistics (Dr. Hanna), School of Rehabilitation Science, McMaster University, Hamilton, ON,Canada. This study was funded by the Canadian Institute for Health Research (CIHR) and by an unrestricted grant from the AstraZeneca/ Firestone Institute for Respiratory Health collaboration. Dr. Mandhane was a CIHR Strategic Training Fellow in the Canadian Child Health Clinician Scientist Program and received an award from the CHEST Foundation. Dr. Sears holds the AstraZeneca Chair in Respiratory Epidemiology,McMaster University. Piush Mandhane, MD, PhD, Aberhart Centre No. 1, Room 7316A, 11402 University Ave, Edmonton, AB, Canada T6G 2J3; e- mail: mandhane@ualberta.ca 背景和目的 在月经周期中哮喘和特应性具有明显改变。 我们假设哮喘的特征［例如症状、 反映 气道炎症的呼出气一氧化氮 (eNO)水平、 肺功能和特应性等］与月经周期中雌激素和孕激素水平的 变化相关， 口服避孕药 (OC) 的女性这种改变减弱。 方法 选择 17 例女性哮喘患者， 在整个月经周期中， 每天观察其症状， 检测 eNO、 肺功能、 17β- 雌二醇和孕酮水平， 隔日进行皮肤过敏原点刺实验 (SPT)。 结果 每天访视的534例患者中有526例 (98.5%) 完成实验。不使用OC的女性 (n =8)平均eNO水平 (48.2 ppb， 95% CI 43.1 ～ 53.3 ppb) 高于口服