P53和Ki-67在喉鳞状细胞癌中的表达及与短期预后的关系.PDF

临床与病理杂志 2017, 37(3) 552 J Clin Pathol Res doi: 10.3978/j.issn.2095-6959.2017.03.018 View this article at: /10.3978/j.issn.2095-6959.2017.03.018 P53和Ki-67在喉鳞状细胞癌中的表达及与短期预后的关系 郭珍珍1，王春2，孙振柱2 (1. 石河子大学医学院，新疆 石河子 832000；2. 新疆维吾尔自治区人民医院病理科，乌鲁木齐 830000) [摘　要] 目的：探讨P53和Ki-67在喉鳞状细胞癌(laryngeal squamous cell carcinoma，LSCC)中的表达情 况及临床病理参数和短期预后相关分析。方法：选择手术切除LSCC标本35例，肿瘤分期均为 T3~4N0M0。采用SP法染色进行P53和Ki-67免疫组织化学标记，结合临床病??参数和2年随访结果 及无病生存情况进行统计学分析。结果：LSCC标本P53阳性率为60.00%；2年复发率P53阳性患者 76.19%高于P53阴性28.59%，差异具有统计学意义(P=0.013)。年龄大小、是否抽烟、增殖指数高 低及肿瘤不同分级方面，患者2年内复发率差异均无统计学意义。T3~4N0M0分期患者的短期预后 与P53表达高低相关。结论：P53的过表达对晚期LSCC短期预后评估具有一定的临床意义，可考虑 作为晚期LSCC分层治疗指标。 [关键词] 喉鳞状细胞癌；P53；Ki-67；免疫组织化学；预后 Expression of P53 and Ki-67 in laryngeal squamous cell carcinoma and the short-term prognosis GUO Zhenzhen1, WANG Chun2, SUN Zhenzhu2 (1. Shihezi University Medical College, Shihezi Xinjiang 832000; 2. Department of Pathology, Xinjiang Uygur Autonomous Region People’s Hospital, Wulumuqi 830000, China) Abstract Objective: To study the expression of P53 and Ki-67 protein in laryngeal squamous cell carcinoma (LSCC) and the relation with parameters of clinicopathology and short-term prognosis. Methods: The expression of P53 an Ki-67 was examined by SP immunohistochemistry in 35 cases of LSCC, with tumor stage were T3–4N0M0. The results were subjected to statistics analysis, combined with the clinical pathologic data and short-term prognosis. Results: In 35 cases LSCC, 2-year recurrence of the P53 positive expression was 60.0