艾滋病毒感染后疾病进展和治疗的数学模型及其动力学性态_英文_.pdf

CHINESE JOURNAL June 2010 Vol. 27 No. 3 OF ENGINEERING MATHEMATICS Article ID:1005-3085(2010)03-0534-15 Mathematical Modeling and Dynamics of HIV Progression and Treatment? WANG Yan, ZHOU Yi-cang (Department of Applied Mathematics, Xi’an Jiaotong University, Xi’an 710049) Abstract: This article presents a brief review on the modeling and dynamics of HIV infection in vivo. We introduce typical mathematical models on the interaction between CD4+ T- cells and virus particles, as well as the drug therapy. We focus on theoretical results and simulations of ODEs, DDEs, integro-di?erential equations and impulsive di?erential equations. Parameter values of those models are collected in a table for reader’s reference. Keywords: HIV; T-cells; drug resistance; drug therapy; time delay; asymptotic stability Classi?cation: AMS(2000) 92D30 CLC number: O175.1; R512.91 Document code: A 1 Introduction AIDS (Acquired Immunode?ciency Syndrome) is one of the most serious, deadly diseases in human history. AIDS, caused by the human immunode?ciency virus (HIV), has spread in successive waves in various regions around the globe. The estimated number of persons living with HIV worldwide in 2008 was 33.4 million. The number of newly infected with HIV in 2008 is 2.7 million[1]. HIV needs bonding to the speci?c host cell receptor. The receptor is a CD4 antigen in the membrane of T helpers lymphocytes. When the cell is activated by an antigenic impulse, viral protease ?nishes the process of releasing the virus. These new virions immediately attack next CD4+ T-cells and leads to their destruction. The immune system is exhausted by acceleration of the CD4+ production and destruction, and soon the destruction predominates.