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AntagonistUsedinClinic.PDF
Journal of Organic Chemistry Research 有机化学研究, 2015, 3, 9-15
Published Online March 2015 in Hans. /journal/jocr
/10.12677/jocr.2015.31002
Research Progress of Opioid Receptor
Antagonist Used in Clinic
Qiao Wang1,2, Lang Shu1,2, Ming Liu3, Kaiyuan Shao2, Wenxiang Hu1,2,3*
1School of Chemical Engineering Pharmacy, Wuhan Institute of Technology, Wuhan Hubei
2Beijing Excalibur Space Military Academy of Medical Sciences, Beijing
3School of Life Sciences, Capital Normal University, Beijing
Email: *huwx66@163.com
Received: Jan. 23rd, 2015; accepted: Feb. 4th, 2015; published: Feb. 10th, 2015
Copyright ? 2015 by authors and Hans Publishers Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY).
/licenses/by/4.0/
Abstract
Opioid receptor antagonists are a class of specifically drugs for antagonizing the opioid on opioid
receptors, thereby reducing or reversing the analgesic activity of narcotic agonists. Antagonists
can also eliminate breathing suppression, gastrointestinal disorders and other side effects caused
by the use of the agonist. Antagonists are used in clinic as side effects and coma antidote arising
from excessive usage of analgesic. This paper summarizes several common clinical types of opioid
receptor antagonists and clinical applications. In recent years, antagonists have achieved greater
development, but there are still some deficiencies; further research of opioid receptor antagonists
is needed to get more competitive, safer and simpler novel μ opioid receptor-specific antagonist,
for better use in clinical treatment.
Keywords
Opioid Receptor, General Opioid Receptor Antago
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